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In some cases, cannabis can lead to dissociative states such as depersonalization Aside from a subjective change in perception and mood, the most common short-term physical and neurological effects include increased heart rate, increased appetite and consumption of food, lowered blood pressure, impairment of short-term and working memory, psychomotor coordination, and concentration.
Some users may experience an episode of acute psychosis, which usually abates after six hours, but in rare instances, heavy users may find the symptoms continuing for many days.
sudden cardiac death, and cardiomyopathy have been reported to be temporally associated with cannabis use.
Research in these events is complicated because cannabis is often used in conjunction with tobacco, and drugs such as alcohol and cocaine.
Most of the illicit drug emergency room visits involved multiple drugs.
Heavy, long term exposure to marijuana may have biologically-based physical, mental, behavioral and social health consequences and may be "associated with diseases of the liver (particularly with co-existing hepatitis C), lungs, heart, and vasculature".
A 2010 review found resting blood flow to be lower globally and in prefrontal areas of the brain in cannabis users, when compared to non-users.
No effects were found in those who initiated cannabis use later, or in those who ceased use earlier in adulthood.
Cannabis usually causes no tolerance or withdrawal symptoms except in heavy users.
A 2012 meta-analysis found that the effects of cannabis use on neurocognitive functions were "limited to the first 25 days of abstinence" and that there was no evidence that such use had long-lasting effects, Compared to non-smokers, people who smoked cannabis regularly in adolescence exhibit reduced connectivity in specific brain regions associated with memory, learning, alertness, and executive function.
A study has suggested that sustained heavy, daily, adolescent onset cannabis use over decades is associated with a decline in IQ by age 38.
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- in India and Nepal since the Vedic period dating back to approximately 1500 BCE, but perhaps as far back as 2000 BCE.