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Fort Pitt (now Pittsburgh) at the source of the Ohio River became the main base for settlers moving into the Northwest Territory.The War of 1812 cut off the supply of British goods, stimulating American industry.Following the American Revolution, the village of Pittsburgh continued to grow.One of its earliest industries was boat building for settlers of the Ohio Country.During Pontiac's Rebellion, native tribes conducted a siege of Fort Pitt for two months until Colonel Henry Bouquet relieved it after the Battle of Bushy Run.Fort Pitt is notable as the site of an early use of smallpox for biological warfare.
On March 18, 1816, the 46-year-old local government became a city.
In the 1830s, many Welsh people from the Merthyr steelworks immigrated to the city following the aftermath of the Merthyr Rising.
By the 1840s, Pittsburgh was one of the largest cities west of the Allegheny Mountains.
Michael Bezallion was the first to describe the forks of the Ohio in a 1717 manuscript, and later that year European fur traders established area posts and settlements.
During 1753–54, the British hastily built Fort Prince George before a larger French force drove them off.